After escaping with Newt and Hicks from the alien planet, Ripley crash lands on Fiorina 161, a prison planet and host to a correctional facility. Unfortunately, although Newt and Hicks do not survive the crash, a more unwelcome visitor does. The prison does not allow weapons of any kind, and with aid being a long time away, the prisoners must simply survive in any way they can.

The only survivor of the Nostromo, Ripley is discovered in deep sleep half a century later by a salvage ship. When she is taken back to Earth, she learns that a human colony was founded on the same planet where the aliens were first found. After contact with the colony is lost, she finds herself sent back to the planet along with a team of warriors bent on destroying the alien menace forever, and saving any survivors -- if any remain.