The story of the early, murderous roots of the cannibalistic killer, Hannibal Lecter – from his hard-scrabble Lithuanian childhood, where he witnesses the repulsive lengths to which hungry soldiers will go to satiate themselves, through his sojourn in France, where as a medical student he hones his appetite for the kill.

Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.