Leonard and Penny renew their vows, this time inviting their friends and family for wedding party; they also learn that marriage is about compromise, and figure out how to support each other. Sheldon and Amy experiment to take their relationship to the next level, and after an emotional struggle they move in together in Penny's old apartment. Howard and Bernadette realise that being a parent is a full-time job, but with the help of their friends they manage to find joy in raising their child. When his friends tell him he's extremely spoiled, Raj decides to stop taking his father's money and learn how to make ends meet.

When Earth is taken over by the overly-confident Boov, an alien race in search of a new place to call home, all humans are promptly relocated, while all Boov get busy reorganizing the planet. But when one resourceful girl, Tip, manages to avoid capture, she finds herself the accidental accomplice of a banished Boov named Oh. The two fugitives realize there’s a lot more at stake than intergalactic relations as they embark on the road trip of a lifetime.

Leonard returns from his North Sea expedition to find that his relationship with Penny involves more beta-testing than he’s ever done in a lab. Howard’s attachment issues with the women in his life in particular and Raj’s social breakthrough with women in general provide more laughs. Bernadette and Amy stand staunchly by the men in their life, even when they’re sitting in marathon role-playing games. Sheldon sees his mom in a totally different way, parties with James Earl Jones, establishes a (sort of) bond with his idol Professor Proton and makes a scientific breakthrough that breaks down before you can say Science Friday.