With only three weeks left in his three year contract, Sam Bell is getting anxious to finally return to Earth. He is the only occupant of a Moon-based manufacturing facility along with his computer and assistant, GERTY. When he has an accident however, he wakens to find that he is not alone.

Rascal. Joker. Dreamer. Genius... You've never met a college student quite like "Rancho." From the moment he arrives at India's most prestigious university, Rancho's outlandish schemes turn the campus upside down—along with the lives of his two newfound best friends. Together, they make life miserable for "Virus," the school’s uptight and heartless dean. But when Rancho catches the eye of the dean's daughter, Virus sets his sights on flunking out the "3 idiots" once and for all.

In 1933 New York, an overly ambitious movie producer coerces his cast and hired ship crew to travel to mysterious Skull Island, where they encounter Kong, a giant ape who is immediately smitten with the leading lady.