The Doctor faces the end of his life as the Master's plans hurtle out of control. With the sound of drums growing louder, and an ancient trap closing around the Earth, the Doctor and Wilf must fight alone. But sacrifices must be made, and the deadly prophecy warns: "He will knock four times."

The Ood have given a warning to The Doctor. The Master is returning yet that is not the biggest threat. A darkness is coming which brings with it The End of Time.

The series introduces Pearl Mackie as Bill Potts, and also features Matt Lucas as Nardole. Michelle Gomez and John Simm return as their respective incarnations of the Master. The main story arc for the first half of the series revolves around the Doctor and Nardole occupying themselves at a university while they guard an underground vault containing Missy. Missy later travels with the team in the TARDIS, and eventually partners with her previous incarnation as they battle a Cyberman onslaught.

When the hospital she works at is transported to the moon, medical student Martha Jones joins forces with The Doctor to hunt down an alien fugitive before the oxygen runs out