University physicists Leonard and Sheldon know whether to use an integral or a differential to solve the area under a curve. But they don't have a clue about girls. Or dating. Or clothes. Or parties. Or having fun. Or, basically, life. So when a pretty blonde named Penny moves in the apartment across the hall, the guys decide to get an education outside of the classroom. Boys, you have a lot to learn.

Worlds collide in Season 3! A love affair with Penny has opened a big, wide, wonderful world of romance for Leonard. But Sheldon likes the world just the way it was, thank you. All of which makes for a zany comic triangle with brainy, clueless Sheldon and practical, grounded Penny hilariously vying for the role of hypotenuse.

This season the Big Bang gang’s romantic universe expands. On the rebound from Penny, Leonard falls into the arms of Raj’s sister Priya. Sheldon gets a girlfriend, or rather a friend who is a girl: Amy, a dour neurobiologist who declares herself besties with Penny. Howard and Bernadette heat up. And so do Raj and Bernadette (at least in Raj’s Bollywood daydream).

In season five, Penny and Leonard's relationship is relaunched in full "beta test" mode, while Sheldon, Howard, and Raj discover the feminine mystique is something that cannot be easily graphed or calculated. As Sheldon makes begrudging amendments to his "Relationship Agreement" with his "friend-who-happens-to-be-a-girl" Amy Farrah Fowler, Raj contemplates an arranged marriage, and Howard is all-systems-go for both is NASA space launch and wedding to the spirited Bernadette.

Leonard returns from his North Sea expedition to find that his relationship with Penny involves more beta-testing than he’s ever done in a lab. Howard’s attachment issues with the women in his life in particular and Raj’s social breakthrough with women in general provide more laughs. Bernadette and Amy stand staunchly by the men in their life, even when they’re sitting in marathon role-playing games. Sheldon sees his mom in a totally different way, parties with James Earl Jones, establishes a (sort of) bond with his idol Professor Proton and makes a scientific breakthrough that breaks down before you can say Science Friday.

CBS在新喜剧上表现无力下把歪脑筋动到《生活大爆炸 The Big Bang Theory》的Sheldon身上，早前他们宣布开发《生活大爆炸》衍生前传剧，現CBS确定预订命名为《小谢尔顿 Young Sheldon》的衍生剧，顾名思义就是以Sheldon Cooper 为主角。该剧定于17-18年度播出。 这部喜剧主角不是Sheldon成年版，而是以他9岁时为背景，剧集也会以《马尔柯姆的一家 Malcolm in the Middle》的单镜头家庭喜剧方式制作，讲述Sheldon当年在德州东部的家庭及学校生活。Chuck Lorre与Bill Prady为主创兼执行制片﹑Steve Molaro﹑Todd Spiewak与在《生活大爆炸》饰演Sheldon的Jim Parsons为制作人兼执行制片。 在过往剧情中，可得知Sheldon的家人包括哥哥George﹑异卵双胞胎姐妹Missy﹑有宗教信仰的妈妈Mary Cooper，以及酗酒的爸爸George Cooper。另外Sheldon还有外婆（Meemaw）及外公（Pop Pop），外公在Sheldon 5岁时去世。 该剧由Jon Favreau执导， Iain Armitage将饰演年轻版的Sheldon Cooper﹑ Zoe Perry饰演其母亲Mary Cooper﹑Lance Barber饰演Sheldon的父亲﹑Raegan Revord及Montana Jordan饰演Sheldon的兄妹（姐？）﹑Annie Potts饰演外婆。