流感为什么难以治愈？ 病毒如何变异、传播和致病？ 是流感本身更致命，还是流感导致的社会恐慌更致命？ 流感为什么有季节性？哪些因素影响流感的暴发？ 在对抗流感的过程中，药物是带来了革命性的变化，还是仅仅给了人们一种安全感？ 我们距离找到一种有效的流感疫苗还有多远？ 从文明出现曙光至今，流感一直伴随着我们，作为世界十大致命疾病之一，困扰着地球上所有的文明和社会。 1918年的大流感是一段令人毛骨悚然的历史，它比战争更残酷，是有史以来死亡人数最多的全球性瘟疫，造成5000万至一亿人丧生，超过5亿人感染；1957年暴发于香港的H2N2型流感，夺去了全球约200万人的生命；1968年，大规模的禽流感再次在亚洲暴发；1975年和2009年暴发于美国和墨西哥的猪流感，致死人数数十万；21世纪，我们还遭遇了SARS，MERS，埃博拉，新冠肺炎等由病毒引起的流行性疾病…… 杰里米·布朗博士，探究了人类发现流感病毒并与之抗争的历史，审视了与流感相关的若干重要问题，旨在提供全面综合的历史的同时，探索一条治愈流感的未来路线图。

In 1918, the Italian-Americans of New York, the Yupik of Alaska and the Persians of Mashed had almost nothing in common except for a virus--one that triggered the worst pandemic of modern times and had a decisive effect on the history of the twentieth century. The Spanish flu of 1918-1920 was one of the greatest human disasters of all time. It infected a third of the people on Earth--from the poorest immigrants of New York City to the king of Spain, Franz Kafka, Mahatma Gandhi and Woodrow Wilson. But despite a death toll of between 50 and 100 million people, it exists in our memory as an afterthought to World War I. In this gripping narrative history, Laura Spinney traces the overlooked pandemic to reveal how the virus travelled across the globe, exposing mankind's vulnerability and putting our ingenuity to the test. As socially significant as both world wars, the Spanish flu dramatically disrupted--and often permanently altered--global politics, race relations and family structures, while spurring innovation in medicine, religion and the arts. It was partly responsible, Spinney argues, for pushing India to independence, South Africa to apartheid and Switzerland to the brink of civil war. It also created the true "lost generation." Drawing on the latest research in history, virology, epidemiology, psychology and economics, Pale Rider masterfully recounts the little-known catastrophe that forever changed humanity.