Patrick Melrose is a man from a very privileged yet traumatic childhood in the 1980s. Patrick's father was a very abusive man and Patrick's mother put up with his behavior. Eventually, Patrick's trauma led him down a path of adulthood addiction and severe substance abuse in New York.

A political, family drama set in Florence in the early 15th century. Cosimo de'Medici finds himself at the helm of his supremly wealthy, banking dynasty family, when his father, Giovanni dies suddenly. However Cosimo is concealing a dangerous secret - Giovanni was murdered. Now Cosimoand his brother must unearth his killer in order to protect the wealth and power of the family.