Years after the Racoon City catastrophe, survivors travel across the Nevada desert, hoping to make it to Alaska. Alice joins the caravan and their fight against hordes of zombies and the evil Umbrella Corp.

When the creator of a popular video game system dies, a virtual contest is created to compete for his fortune.

When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain the outbreak.

As the city is locked down under quarantine, Alice finds out that the people that died from the previous incident at the Umbrella Corporation have turned into zombies. She then joins a small band of elite soldiers, who are enlisted to rescue the missing daughter of the creator of the mutating T-virus. Once lack of luck and resources happen, they begin to wage an exhilarating battle to survive and escape before the Umbrella Corporation erases its experiment from the face of the earth.

Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.