Brothers Edward and Alphonse Elric suffer a tragic loss after attempting forbidden alchemy to bring back their deceased mother. Edward loses a leg and an arm, while Alphonse's body is entirely taken. To save his brother, Edward binds Alphonse's soul to a suit of armor. Now, the brothers seek the Philosopher’s Stone to restore their bodies. Edward becomes a State Alchemist, and they face threats from Scar, a vengeful warrior, and the Homunculi, mysterious enemies linked to the Philosopher's Stone. As the season unfolds, they uncover deeper mysteries about the Stone and the dark forces controlling it, while their journey tests their bond and moral beliefs.

失去了右手和左腿的爱德华与失去了整个身体的艾尔为了找回失去的一切踏上了寻找拥有极大力量的“贤者之石”的旅程，由于采用了机械义肢，人们将这位国家炼金术师称为“钢之炼金术师”。这部作品中时时刻刻给人以莫名的震撼，两兄弟冒着生命危险发动了禁忌的“人体炼成”，“只是为了再见一次妈妈的笑脸……”，结果他们失败了。为了寻找贤者之石，抛弃所有的牵挂，那一天他们一把火烧掉了自己的家，然后在爱德华的怀表上多了一行字——“别忘了10月3日”。炼金术是一种等价交换的法术，他们找齐了全部与人体等价的物质，然而，什么能够代替灵魂？