中世纪，炼金术士们以巨大的代价从恶魔的手中得到了传说中的永生之酒，凡是喝下永生之酒的人们，正如它的名字那样，将会得到永远不会死亡的肉体。永生之酒带来了希望，却也引发了空前绝后的灾难，因为私欲和利益，与此酒相关的人士一个接着一个失去了踪迹。随着禁酒令的颁布，永生之酒的下落逐渐成为了谜题，然而数年过后，有关它重出江湖的消息再次被传得沸沸扬扬，在纽约的黑道中激起了涟漪。 身怀绝技的少年洛菲（吉野裕行 配音）、不老不死的炼金术士阿洛瓦（宫本充 配音）、个性莽撞大大咧咧的夫妻艾萨克（小野坂昌也 配音）和哈文特（青木静香 配音），这些身份从无交集的人们，也为了追寻永生之酒的下落而走到了一起。

Even in his past life, Cid's dream wasn't to become a protagonist or a final boss. He'd rather lie low as a minor character until it's prime time to reveal he's a mastermind...or at least, do the next best thing-pretend to be one! And now that he's been reborn into another world, he's ready to set the perfect conditions to live out his dreams to the fullest. Armed with his overactive imagination, Cid jokingly recruits members to his organization and makes up a whole backstory about an evil cult that they need to take down. Well, as luck would have it, these imaginary adversaries turn out to be the real deal-and everyone knows the truth but him!