A brilliant plastic surgeon creates a synthetic skin that withstands any kind of damage. His guinea pig: a mysterious and volatile woman who holds the key to his obsession.

18-year-old Angelina shuffles between school, a dead-end job, her exploitative boyfriend, and home, where her life consists of cleaning up after her alcoholic mother and protecting her younger sister from their menacing stepfather. After arranging an escape to San Francisco with her best friend Andrew, she soon finds herself dating a coke-addicted attorney and becoming immersed in the local porn industry, mentored by lesbian director Margaret, who has more than just a professional interest in Angelina's talents.

When 11-year-old Riley moves to a new city, her Emotions team up to help her through the transition. Joy, Fear, Anger, Disgust and Sadness work together, but when Joy and Sadness get lost, they must journey through unfamiliar places to get back home.