In the year 2019, a plague has transformed almost every human into a vampire. Faced with a dwindling blood supply, the fractured dominant race plots their survival; meanwhile, a researcher works with a covert band of vampires on a way to save humankind.

A depressed musician reunites with his lover in the desolate streets of Detroit. Though their romance has endured several centuries, it is tested by the arrival of her capricious and unpredictable younger sister.

In the 19th century, Dracula travels to London and meets Mina, a young woman who appears as the reincarnation of his lost love.

Famed monster slayer Gabriel Van Helsing is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula. Anna Valerious reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family.