The show follows the epic journey of the monk Tang Sanzang and his three disciples-Sun Wukong (the Monkey King), Zhu Bajie (Pigsy), and Sha Wujing (Sandy)-as they travel westward in search of Buddhist scriptures.

The series begins with the mother-less child, Lin Daiyu - whose beauty and intelligence surpasses all, moving into the family compound of her maternal grandmother in the capital. There, the child meets numerous relatives, one of whom is Jia Baoyu, her mother's nephew and male protagonist. Baoyu was born with a piece of jade in his mouth and, so, is treated like a fragile egg and spoiled by his grandmother. He often spends his time with his female cousins and maids instead of tending to his studies.

关中一个普通的小镇——七俠镇，这里有一家同福客栈。就是这间不起眼的客栈，因缘巧合之下汇聚了一群性格各异又活泼搞怪的年轻人：武功高强但初入江湖的郭芙蓉（姚晨 饰）、老板娘佟湘玉（闫妮 饰）、金盘洗手的神偷白展堂（沙溢 饰）、满腹经纶怀才不遇的吕秀才（喻恩泰 饰）、厨师李大嘴（姜超 饰）等等。这群年轻人在同一屋檐下演绎了一幕幕经典的搞笑场面，在欢笑与眼泪中陪伴观众们一起渐渐成长。