In 1958 New York, Midge Maisel’s life is on track– husband, kids, and elegant Yom Kippur dinners in their Upper West Side apartment. But when her life takes a surprise turn, she has to quickly decide what else she’s good at – and going from housewife to stand-up comic is a wild choice to everyone but her.

An aspiring dancer moves to New York City and becomes caught up in a whirlwind of flighty fair-weather friends, diminishing fortunes and career setbacks.