Wandering her rambling old house in her boring new town, 11-year-old Coraline discovers a hidden door to a strangely idealized version of her life. In order to stay in the fantasy, she must make a frighteningly real sacrifice.

Inventor Flint Lockwood creates a machine that makes clouds rain food, enabling the down-and-out citizens of Chewandswallow to feed themselves. But when the falling food reaches gargantuan proportions, Flint must scramble to avert disaster. Can he regain control of the machine and put an end to the wild weather before the town is destroyed?

Dr. Adrian Helmsley, part of a worldwide geophysical team investigating the effect on the earth of radiation from unprecedented solar storms, learns that the earth's core is heating up. He warns U.S. President Thomas Wilson that the crust of the earth is becoming unstable and that without proper preparations for saving a fraction of the world's population, the entire race is doomed. Meanwhile, writer Jackson Curtis stumbles on the same information. While the world's leaders race to build "arks" to escape the impending cataclysm, Curtis struggles to find a way to save his family. Meanwhile, volcanic eruptions and earthquakes of unprecedented strength wreak havoc around the world.

Carl Fredricksen spent his entire life dreaming of exploring the globe and experiencing life to its fullest. But at age 78, life seems to have passed him by, until a twist of fate (and a persistent 8-year old Wilderness Explorer named Russell) gives him a new lease on life.