Attorneys Kensuke Komikado and Machiko Mayuzumi receive a request from a general hospital. They go up against veteran attorney Kazuma Kujou who is trying to extract money from the general hospital by a medical malpractice lawsuit.

Mysteries are revealed like the words "Simple Plan," "Third Secret of Fatima" and also the mysterious white man which are all mentioned in the movie "SPEC: Heaven".

High school student Saya Toma lost her parents and younger brother in an airplane accident. Detective Akio Kondo came and told her "your family has a high possibility that they were killed by people who have spec." That was the first time she heard of "spec". 6 years later, Saya Toma, who has never forgotten what the Detective said, decides to become a detective. She returns to Japan after receiving training by the FBI in the United States. Saya Toma is assigned to work unsolved cases in the Public Security Bureau. Meanwhile, because of Satoshi Chii's scheme, Juichi Ninomae considers Saya Toma his parents' enemy and tries to push her to the edge. Satoshi Chii's scheme has also caused Saya Toma and Juichi Ninomae to forget that they are brother and sister. The siblings are headed to a life-staking fight. A girl named Maho Ueno becomes involved in their fight. To protect Maho Ueno, Saya Toma uses "spec".

Kazuhiko Kogure, who is a 2nd grade student in middle school, falls off from one of the school's rooftop. There were other male students on the roof when Kazuhiko Kogure fell off. According to the other students there, Kazuhiko Kogure tried to jump to another school building, but missed. Fortunately, Kazuhiko Kogure only fractured his leg and ribs. According to Kazuhiko Kogure's mother Hidemi, the school insists it was students playing around and did not involve bullying. Hidemi though, doesn't believe it, because Kazuhiko Kogure has a fear of heights. Hidemi goes to see attorney Machiko Mayuzumi and Machiko decides to take her case, but she asks for fellow attorney Kensuke Komikado's help. Meanwhile, the school hires attorney Teshigahara Isao.

Set one year after the fight between detectives Saya Toma, Takeru Sebumi, and Satoshi Chii. More confrontations ensues between the detectives at the Unidentified Crimes Unit of the Tokyo Metropolitan Police Department. Takeru Sebumi returns after taking a break due to his eye problems. Kenzo Ichiyanagi is appointed section chief, while Kotaro Nonomura is demoted. New member Shu Kikkawa joins the team.

应届大学毕业生照子（长泽雅美 饰）找工作面试时总会被问的哑口无言，发现自己的人生阅历少之又少，在一次面试过程中，照子被问到自己的理想是什么，受到爱四处旅游的哥哥的影响，照子突然大声喊出：“想在恒河游蝶泳！”令人大跌眼镜的是，照子真的只身一人来到了印度。 迎接她的是全然陌生的国度、习惯、信仰。之前认为理所当然的行为准则到了印度通通不适用。起初的不适应让照子惊慌失措，在经历的接二连三的乌龙事件后，照子遇见了同样来自日本在印度旅行的青年慎悟（塚本高史 饰）。慎悟给了照子很多建议和帮助，满以为遇到贵人的照子，在不防备间被慎悟偷走了行李和钱。心灰意冷的照子却在最低谷处遇上了一个好心的印度家庭，不仅提供吃住，还把照子当自家孩子看。但此行的目的仍未达到，哪怕不舍离开，照子还是踏上了去往恒河的路。一路风尘和曲折，但回过头尽是奇妙的体验，且这些经历仅此在印度发生。

经历了那场刻骨铭心的爱恋，永尾完治（织田裕二 饰）和赤名莉香（铃木保奈美 饰）最终奔向不同的人生之路，丸子与里美（有森也实 饰）结为夫妇，莉香依旧孑然一身，不变的只有那阳光般灿烂的笑容。转眼三年过去，这一天，莉香奉命和公司后辈大潼（筒井道隆 饰），而出差的地点竟是一个让她心有所动的名字——爱媛县的松山，丸子的故乡。旅途中，莉香和大潼各自吐露着对感情的看法。 在即将启程返回东京的时候，莉香暂时告别大潼，独自绽开一段短暂的追忆之旅。有过一面之缘的小镇，爱恋之人出生生长的街道，往昔美好的回忆扑面而来……

2005年1月9日放送的一集90分钟左右的SP电视剧（《三枚起请》）。故事就从小虎讨债偶然看了“三枚起请”开始展开，好容易能够学习落语了，完全不明状况的小虎立即提出要学习“三枚起请”。先来解释一下这个落语故事吧。 主要人物：仏壇屋の源兵衛，下駄屋の喜六，指物屋の清八，小山(おやま＝女郎)の小輝(こてる)，茶屋の女将 三个男人在同一个女郎/游女那里得到了起请（就是向神佛起誓的誓言纸）。正常来说从良前女子写给自己中意男子，一个女子只能给一个男子。男人们发现自己被骗了之后就去找游女，并且告诉他“说谎的一张起请会杀死熊野的使者三只乌鸦”，因为熊野誓纸相当有名，而一旦毁约，神佛的使者乌鸦会死去。但是游女却引用会把高杉晋作做的“三千世界の烏を殺し、ぬしと朝寝がしてみたい”（天下的乌鸦都死了，就能睡好觉了<===随便翻ing，因为游女都是夜间工作，早晨吵闹的乌鸦使得她们和客人不能好好睡觉。） （= =………………严重BS自己的语言功能ing） 而小虎完全不能理解故事的背景和笑点，通过师母的指点找到龙二，想让他教自己这个落语。之间两人解决了小虎流星会的麻烦，也卷进了MEGUMI和一众男人的故事中，通过这个，小虎讲起了自己的“五枚起请”，将落语和现实生活结合在一起，得到了意想不到的欢迎……………… 之后因崭新的剧情构成而反映强烈，所以顺势于春季推出了电视剧版。电视剧版的剧情承接自《三枚起请》。

《LAST FRIENDS 最后的朋友》特别篇

亚也（沢尻エリカ饰）逝去后，池内一家人内心的悲痛渐渐平复，生活也重新走上轨道。而亚也的影响依然无处不在：留在人们记忆中的除了她的音容笑貌外，她已成为勇气和信念的化身。为了能帮助更多的人，妹妹亚湖（成海璃子饰）选择成为一名护士。亚也生前的恋人麻生（錦戸亮饰）也当上了神经科医师，为探究“脊椎小脑变性症”这种疾病而努力。 亚湖注意到麻生似乎变得有些消沉，对待人和事都不怎么积极，她为此忧心忡忡。一日，病人長島（岡本杏理饰）无意间看到亚也的文字，好奇的她向麻生询问亚也的事迹，记忆的匣子打开了，麻生终于敞开自己的心扉，细细讲述亚也的故事……