In Season 2, after Jesse accidentally discovered that God is absent from Heaven, the three of them set out on a road trip to find Him, all while being hunted by the Saint of Killers, an unstoppable, mythical killer from Hell. The trio’s pursuit led them to New Orleans, where they dodged local gangsters, dangerous agents, and other unimaginable mayhem on their way to uncovering an even bigger secret. Now, with Tulip’s life and Cassidy’s friendship in the balance, Jesse must rely on a mysterious figure from his past in order to save his friends and continue on with his mission.