The main cast were Frost, Corbett, Cleese, Barker, Sheila Steafel and Nicky Henson. Musical interludes were provided by Julie Felix, while Tom Lehrer also performed songs in a few episodes.
The production team of The Frost Report comprised some of the finest comedic minds of Britain in the 1960s, with writers and performers who would go on to become famous names in different television shows. They included future Goodies members Bill Oddie and Tim Brooke-Taylor, and also Frank Muir, Denis Norden, Barry Cryer, Marty Feldman, Ronnie Barker, Ronnie Corbett, Dick Vosburgh, Anthony Jay (Yes Minister and Yes Prime Minister) and future Python members Graham Chapman, John Cleese, Eric Idle, Terry Jones and Michael Palin. It was while working on The Frost Report that the future Pythons developed their unique writing styles that would become so significant later.
A special one-off episode was broadcast on Easter Monday (24 March) 2008. It ran for ninety minutes being followed by a full episode featuring the classic Cleese/Barker/Corbett class sketch, which parodied the British class system.