读过《Protein Degradation》 🌕🌕🌕🌕🌑
略读速食。以泛素-蛋白酶体体系为核心的蛋白降解详细介绍，比较好地平衡了功能和结构的比重（大约2:1）。学习生物好麻烦啊（不。。。
Protein Degradation [Book] Douban
author:
Mayer, John (EDT)/ Ciechanover, Aaron J. (EDT)/ Rechsteiner, Martin (EDT)
publishing house:
John Wiley & Sons Inc
2005
- 5
The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series,
and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.