Following an unexpected tragedy, child psychologist Malcolm Crowe meets a nine year old boy named Cole Sear, who is hiding a dark secret.

In the year 2044, time travel has not yet been invented but in 30 years it will have been. When the mob wants to get rid of someone, they will send their target into the past where a looper, a hired gun, like Joe is waiting to mop up. Joe is getting rich and life is good until the day the mob decides to close the loop, sending back Joe's future self for assassination.

Welcome to Sin City. This town beckons to the tough, the corrupt, the brokenhearted. Some call it dark… Hard-boiled. Then there are those who call it home — Crooked cops, sexy dames, desperate vigilantes. Some are seeking revenge, others lust after redemption, and then there are those hoping for a little of both. A universe of unlikely and reluctant heroes still trying to do the right thing in a city that refuses to care.

A burger-loving hit man, his philosophical partner, a drug-addled gangster's moll and a washed-up boxer converge in this sprawling, comedic crime caper. Their adventures unfurl in three stories that ingeniously trip back and forth in time.

In 2257, a taxi driver is unintentionally given the task of saving a young girl who is part of the key that will ensure the survival of humanity.