阳光明媚的一天，家中再次发生大混战，汤姆和杰瑞这对冤家你追我赶，飙完汽车开飞机，从屋内达到园子，甚至连睡觉的斯派克也加入战争。在这三个麻烦制造者的联合努力下，房子被夷为平地，满目疮痍。女主人气得将汤姆和杰瑞赶了出去，就在此时，他们看到一则消息。好莱坞制作人策划了一场飙车大赛，胜利者将获得一栋超豪华的别墅。两个家伙大喜过望，遂从废品场找来零件，东拼西凑做成了自己的赛车。
大赛如约举行，参赛者来自四面八方，各怀绝技，从美国到墨西哥，从北美洲到亚马逊丛林，从天空到海洋，超级紧张刺激的十项全能比赛吸引了所有人的眼球……

Meet the Griffins: Peter, the big loveable oaf who always says what's on his mind. Lois, the doting mother who can't figure out why her baby son keeps trying to kill her. Their daughter Meg, the teen drama queen who's constantly embarrassed by her family. Chris, the beefy 13-year-old who wouldn't hurt a fly, unless it landed on his hot dog. Stewie, the maniacal one-year-old bent on world domination. And Brian, the sarcastic dog with a wit as dry as the martinis he drinks. The animated adventures of this outrageous family will have your whole family laughing out loud.

2001 film directed by Lawrence Guterman

2015 live-action/animated film directed by Paul Tibbitt and Mike Mitchell