This story is based on the novel "Jo no mai" by Tomiko Miyao which is based on the life of painter Shōen Uemura (1875–1949), the first woman to be awarded the Order of Culture. The title refers to the masterpiece bijinga ("picture of a beautiful woman") that Uemura painted at the age of 61. The main character, Tsuya Shimamura, is born in Kyoto as the second daughter of a tea trader who dies before her birth. Tsuya, who loves painting more than anything and is hopeless at housework, attends art school and at age 15 receives the name Shōsui (from the characters for "pine" and "green") from her teacher. The crown prince of England purchases one of her works, propelling her to fame overnight. The novel portrays the remainder of her stormy life, during which she is impregnated by her teacher and raises a fatherless child; through it all she devotes herself to her painting, undaunted.

Set in Kyoto in the last days of the Edo Period, the bloody conflict continues between local feudal domains, which aim to overthrow the Tokugawa Shogunate, and the Shogun's police and city patrol. Tajuro Kiyokawa, once the master of the sword but now a depraved samurai who left his domain putting aside his past ambition, barely makes ends meet. Toyo, a woman who runs a tavern next door, feels affection for Tajuro who guards her place against nasty customers, but he never realizes Toyo's feelings.

In Osaka during the Edo period, ruler Sanada Yukimura was in losing position, fearing Toyotomi's blood descendents would end, he impregnates one of five Shinano female ninja with the seed of Toyotomi Hideyoshi in hopes of continuing the bloodline. Princess Sen and the five female ninja escape from Osaka castle by blending in with the handmaidens. Lord Tokugawa Ieyasu who was supposed to rule all under the heavens was informed of this secret. So Ieyasu orders five samurai of the Iga Ninja clan (brought by Hattori Hanzo) to stop the Toyotomi bloodline by killing the Kunoichi ninja. An attack of ninja magic arts unfolds in a battle of the sexes.