After spending several months in an orbiting lab, three astronauts prepare to return to Earth only to find their de-orbit thrusters won't activate. After initially thinking they might have to abandon them in orbit, NASA decides to launch a daring rescue. Their plans are complicated by a hurricane headed towards the launch site—and a shrinking air supply in the astronauts' capsule.

On the outskirts of town, the hard-nosed Vienna owns a saloon frequented by the undesirables of the region, including Dancin' Kid and his gang. Another patron of Vienna's establishment is Johnny Guitar, a former gunslinger and her lover. When a heist is pulled in town that results in a man's death, Emma Small, Vienna's rival, rallies the townsfolk to take revenge on Vienna's saloon – even without proof of her wrongdoing.