"Wednesday Club" is a club of middle children who feel they haven't been accepted, that no one pays them any attention. There are seven members, Kong, Phali, Tam, May, Kun, Mac and Pheem, and one ironclad rule: members may not form romantic relationships with each other in order to maintain amity.

This is the story of three friends, renowned in their university. Phaphaeng, fierce and direct, is dubbed the "Queen of One Night Stands." Gale is rich, with the air of a luxurious princess. Queen is their mysterious leader.

The morning after a night of fun, when one of three friends is mysteriously murdered, the two remaining girls become suspects in her death. They soon begin searching for the truth behind the events of that night. The stress of the situation turns their friendship upside down.