Three wealthy children's parents are killed in a fire. When they are sent to a distant relative, they find out that he is plotting to kill them and seize their fortune.

In 1958 New York, Midge Maisel’s life is on track– husband, kids, and elegant Yom Kippur dinners in their Upper West Side apartment. But when her life takes a surprise turn, she has to quickly decide what else she’s good at – and going from housewife to stand-up comic is a wild choice to everyone but her.