An elaborate bank robbery takes place and the gangsters succeed although the FBI had been warned. Jerry Cotton, who is considered accountable for this major failure, loses his badge over this. Being the man he is, Cotton doesn't let the evil-doers forget that he has unfinished business with them.

The first film adaptation of Jerry Cotton. FBI agents Jerry Cotton and Phil Decker are tracing a group of six murderers. Disguised as a vagabond Jerry Cotton infiltrates the gang. Kitty, the leader's girlfriend, soon becomes Jerry's most important helper. With her help, he's able to prevent a bomb's explosion in a school. The deadly attack on a rich collector he can not prevent. The gangsters flee with the loot and a hunt to the death begins ...