After witnessing a brutal massacre, the legendary hero Sartana is ready to do some investigating. Almost everyone in the tiny town of Indian Creek seems eager to buy up the property left behind by the murder victims, and one of them could well be behind the killings. The sheriff himself is not above suspicion, so Sartana must uncover the culprit all on his own.

Three Vietnam vets have become so conditioned to violence that they have developed psychotic tendencies. They kidnap people, brutalize them, then turn them loose and hunt them like animals. However the father of one of their earlier victims is plotting a vicious revenge against them.