An overweight lab technician with low self esteem, brought on by his dominant mother, becomes a serial killer of female nurses.

The madcap life of eccentric Mame Dennis and her bohemian, intellectual arty clique is disrupted when her deceased brother's 10-year-old son Patrick is entrusted to her care. Rather than bow to convention, Mame introduces the boy to her free-wheeling lifestyle, instilling in him her favorite credo, "Life is a banquet, and most poor sons of bitches are starving to death."

At his mother's funeral, stuffy bank clerk Henry Pulling meets his Aunt Augusta, an elderly eccentric with more-than-shady dealings who pulls him along on a whirlwind adventure as she attempts to rescue an old lover.