Yosuke Shinkai is haunted by a past he cannot recall - and a body that is rapidly decomposing. He is a living corpse, unclear who he is or why he has been brought back to life only to suffer again a slow gruesome death. Based on the 1986 horror manga by Hideshi Hino.

Following some trauma in her past that has since been repressed, a young woman is trying to recover her memories with the help of a psychiatrist. During her hypnosis sessions, she repeats the name "Tomie" but is unable to recall where she knows it from. Meanwhile, a police detective is investigating a string of brutal murders, where he also runs across the name "Tomie." How are the two connected?

阴森恐怖的森田医院，院长森田健三（菅田俊 饰）下落不明，4名护士先后辞职。年轻人佐藤文仁（窪塚洋介 饰）因病住进了这个阴冷所在。某晚，文仁的朋友武史（松尾政寿 饰）前来探病，却意外遭遇一个全身赤裸的绝世美女。武史将这个自称富江（宝生舞 饰）的无助女子带回自己的住所，他深深迷恋拥有神秘气质的富江，在此过程中性格也发生巨大的变化。与此同时，森田院长的女儿由美（山口紗弥加 饰）试图调查父亲的行踪，结果发现医院内的医护人员共同坚守着一个不可告人的秘密。这一切都与此前的一起手术以及神秘的富江有关……
本片根据日本著名恐怖漫画家伊藤润二的同名系列漫画改编。