If you are using #Thunderbird with #GnuPG, see https://etaoinwu.com/en/blog/gpgme-2-workaround-for-thunderbird/ to make it work with the newer GpgME 2 stable releases and thus also with #Gpg4win 5.
Maybe our other hints and recommendations for https://wiki.gnupg.org/EMailClients/Thunderbird do interested you, too. ;-)