Meiko Inoue is a recent college grad working as an office lady in a job she hates. Her boyfriend Taneda is permanently crashing at her apartment because his job as a freelance illustrator doesn't pay enough for rent. And her parents in the country keep sending her boxes of veggies that just rot in her fridge. Straddling the line between her years as a student and the rest of her life, Meiko struggles with the feeling that she's just not cut out to be a part of the real world.

A record company office worker named Kanna discovers a punk rock band called Shonen Meriken Sakku 'Brass Knuckle Boys' through the internet and subsequently decides to represent them on behalf of her company. What Kanna did not know was that the Brass Knuckle Boys consists of all middle aged men.

调皮伶俐的少女与一（宮崎あおい 饰）生于人杰辈出的萨摩。适逢历史变革的动荡时代，经过长达两百多年的锁国，日本国内各方面早已出现僵化腐败的局面；而海外列强纷纷崛起，开始将触角伸向这个古老而神秘的国度。由于和外界多有接触，以萨摩为代表的一部分有识之士渴望帮助日本成为现代化的强国，为此他们不惜采用各种手段改变国家的现状。
岛津齐彬（高桥英树 饰）欣赏与一的聪慧与见地，于是将其收为养女，希望培养出一个能从幕府内部改革政府、引导国家走向的女子。肩负着历史使命，更名为笃子的与一开始了将军夫人的艰苦磨练。从此，她的人生将与齐彬、家定（堺雅人 饰）、大久保利通、西乡隆盛（小泽征悦 饰）、庆福（松田翔太 饰）、胜海舟（北大陆欣也 饰）、小松带刀（瑛太 饰）、庆喜（平岳大 饰）等一系列在幕末明治时代占有重要历史地位的人物紧紧纠缠在一起……

13-year-old Sachiko is about to encounter the most difficult moments in her young life. Her father abandons her and her mother attempts to commit suicide by slashing her wrist. Her teacher, whom she relies on heavily, leaves for northern Japan to take another job. Other students start to gossip about Sachiko and her former teacher. Sachiko then drops out of school and attempts to find herself.