After escaping with Newt and Hicks from the alien planet, Ripley crash lands on Fiorina 161, a prison planet and host to a correctional facility. Unfortunately, although Newt and Hicks do not survive the crash, a more unwelcome visitor does. The prison does not allow weapons of any kind, and with aid being a long time away, the prisoners must simply survive in any way they can.

The only survivor of the Nostromo, Ripley is discovered in deep sleep half a century later by a salvage ship. When she is taken back to Earth, she learns that a human colony was founded on the same planet where the aliens were first found. After contact with the colony is lost, she finds herself sent back to the planet along with a team of warriors bent on destroying the alien menace forever, and saving any survivors -- if any remain.

As Susan Hamilton sleeps she dreams that she is another person in an alternative reality as her greatest fears are acted out she is pursued by the notorious serial killer known as the Night Stalker.

Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.