Born under unusual circumstances, Benjamin Button springs into being as an elderly man in a New Orleans nursing home and ages in reverse. Twelve years after his birth, he meets Daisy, a child who flits in and out of his life as she grows up to be a dancer. Though he has all sorts of unusual adventures over the course of his life, it is his relationship with Daisy, and the hope that they will come together at the right time, that drives Benjamin forward.

Outlaw Jesse James is rumored to be the 'fastest gun in the West'. An eager recruit into James' notorious gang, Robert Ford eventually grows jealous of the famed outlaw and, when Robert and his brother sense an opportunity to kill James, their murderous action elevates their target to near mythical status.