Patrick Melrose is a man from a very privileged yet traumatic childhood in the 1980s. Patrick's father was a very abusive man and Patrick's mother put up with his behavior. Eventually, Patrick's trauma led him down a path of adulthood addiction and severe substance abuse in New York.

When a chance encounter brings soldier John Watson into Sherlock's life, it's apparent the two men couldn't be more different, but Sherlock's intellect coupled with John's pragmatism soon forges an unbreakable alliance as they investigate a series of baffling cases together.

After his career is destroyed, a brilliant but arrogant surgeon gets a new lease on life when a sorcerer takes him under her wing and trains him to defend the world against evil.