In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats. When the creatures escape from the briefcase, it sends the American wizarding authorities after Newt, and threatens to strain even further the state of magical and non-magical relations.

When timid bank clerk Stanley Ipkiss discovers a magical mask containing the spirit of the Norse god Loki, his entire life changes. While wearing the mask, Ipkiss becomes a supernatural playboy exuding charm and confidence which allows him to catch the eye of local nightclub singer Tina Carlyle. Unfortunately, under the mask's influence, Ipkiss also robs a bank, which angers junior crime lord Dorian Tyrell, whose goons get blamed for the heist.

After years of increases in the greenhouse effect, havoc is wreaked globally in the form of catastrophic hurricanes, tornadoes, tidal waves, floods and the beginning of a new Ice Age. Paleoclimatologist Jack Hall tries to warn the world while also shepherding to safety his son, trapped in New York after the city is overwhelmed by the start of the new big freeze.

Cobb, a skilled thief who commits corporate espionage by infiltrating the subconscious of his targets is offered a chance to regain his old life as payment for a task considered to be impossible: "inception", the implantation of another person's idea into a target's subconscious.

Dr. Adrian Helmsley, part of a worldwide geophysical team investigating the effect on the earth of radiation from unprecedented solar storms, learns that the earth's core is heating up. He warns U.S. President Thomas Wilson that the crust of the earth is becoming unstable and that without proper preparations for saving a fraction of the world's population, the entire race is doomed. Meanwhile, writer Jackson Curtis stumbles on the same information. While the world's leaders race to build "arks" to escape the impending cataclysm, Curtis struggles to find a way to save his family. Meanwhile, volcanic eruptions and earthquakes of unprecedented strength wreak havoc around the world.