An other-worldly story, set against the backdrop of Cold War era America circa 1962, where a mute janitor working at a lab falls in love with an amphibious man being held captive there and devises a plan to help him escape.

In the summer of 1983, a 17-year-old Elio spends his days in his family's villa in Italy. One day Oliver, a graduate student, arrives to assist Elio's father, a professor of Greco-Roman culture. Soon, Elio and Oliver discover a summer that will alter their lives forever.