Best friends and brilliant physicists Leonard Hofstadter and Sheldon Cooper are geniuses in the lab but socially challenge outside of it. Despite this, Leonard married his beautiful, street-smart neighbour, Penny. And Sheldon, after a long courtship, wed successful neurobiologist Amy. And while aerospace engineer Howard and his adorable microbiologist wife, Bernadette, explore the predicament of being married with two kids, astrophysicist Raj considers a traditional arranged marriage. As the supersmart friends solve quotidian conundrums posed by academia. Family crises and video games, their experiments in domestic bliss never fail to produce hilarious results. But all good theories arrive at a conclusion. The twelfth and final season of "television's perpetual laughter continuum comprises" 24 supercharged episodes that take comedy to the next dimension...and beyond.

After years of only looking out for himself, Sheldon found Amy Farrah Fowler to be the most patient woman to ever walk the earth, and... they did it! Wedding fever continues in season 11.

Leonard and Penny renew their vows, this time inviting their friends and family for wedding party; they also learn that marriage is about compromise, and figure out how to support each other. Sheldon and Amy experiment to take their relationship to the next level, and after an emotional struggle they move in together in Penny's old apartment. Howard and Bernadette realise that being a parent is a full-time job, but with the help of their friends they manage to find joy in raising their child. When his friends tell him he's extremely spoiled, Raj decides to stop taking his father's money and learn how to make ends meet.