Agent Jack Ryan becomes acting Deputy Director of Intelligence for the CIA when Admiral Greer is diagnosed with cancer. When an American businessman, and friend of the president, is murdered on his yacht, Ryan starts discovering links between the man and drug dealers. As former CIA agent John Clark is sent to Colombia to kill drug cartel kingpins in retaliation, Ryan must fight through multiple cover-ups to figure out what happened and who's responsible.

改编自《消失的爱人》作者吉莉安·弗琳的同名小说处女作，讲述记者Camile Preaker，刚刚从精神病院出来就面临了不少麻烦：她必须回到她的家乡小镇去报道两名未成年少女的谋杀事件。Camile一直和她的母亲还有同母异父的古怪妹妹很疏远，但却被逼和她们住在一起。此外随着调查的深入，她发现自己和被害者有很多共同点，在战胜自己心魔的同时她还要慢慢挖掘故事的真相。