RoboCop allows the player to play as RoboCop and to uncover a sinister plot involving OCP, local gangsters dealing a deadly new synthetic drug and a powerful cyborg known only as MIND. As a last hope, RoboCop must capture, destroy, or arrest hostile characters in a desperate search for clues and evidence.

Robocop places you in the titanium-coated-with-kevlar boots of Alex Murphy, killed in the line of duty and resurrected as the cyborg officer Robocop. The 2003 game features a new plot not featured in any of the films. Crime is up in Neo-Detroit due to the rapid proliferation of a new designer drug "Brain Drain," and the efforts of crime lord William Nexx to control its profitable distribution. Meanwhile, a mayoral race is heating up and getting dirty. And of course, mega-corporation OCP's role in all this is almost certain, but unclear.