Chili Con Carnage is a semi-sequel to the Latin-style action game Total Overdose. The game has new missions and a structure fine-tuned for handheld play. The single player mode El Macho is a collection of different mini challenges which do not tell any story but give access to different characters with different gameplay. The game also future two dynamic multiplayer modes: Hangman for up to 4 players on 1 console and Fiesta for Wi-Fi gameplay. There is a massive amount of exotic weapons and the gameplay is over the top, with bullet-time and gravity-defying moves.

Take on the role of Ramiro Cruz in the main story mode, a young man who has just witnessed his dad's murder in classic Mexican fashion (combine harvester through office wall), and now he is on a gun-fueled quest for vengeance through Mexico.